Tissue bath systems are used to isolate tissue and organ preparations for experimental and diagnostic use and allow for a wide range of changes to the subject matter without the interference of other parts of the body coming into play. Bodies are phenomenally interconnected and without being able to isolate tissue, accurate information can’t be determined. Given that a number of uses for the baths involve everything from in vitro muscle to cardiac muscle the results of the use of this equipment are important.
Upper end versions of the bath are modular, allowing labs to purchase one or one hundred depending upon their needs. A full system usually includes glassware, tubing, reservoir, tissue hooks and mounting accessories, a force transducer and a micrometer tension adjuster. They are typically available in 2, 4- and 8- channel configurations and the tissue can be subjected to controlled changes in perfusate, oxygen, drugs and other factors.
Multiple systems can be attached together and most of them are designed to fit into small spaces to allow for maximum use of laboratory space. Many of the more advanced models will include things like ergonomic design, with holders that raise and lower and easy to reach taps for drainage. With the rapid pace of scientific discoveries in health, it’s important for equipment to be as functional and as easy to use as possible.
Tissue bath systems contributed in the 1980’s and 1990’s to discoveries related to exactly how diabetes, hypertension, and arteriosclerosis impacts the body. They’ve helped develop the data to fine tune new lifesaving drugs and can provide a large amount of information about the impacts of different factors on tissue without subjecting a living being to the factors being tested. There are different types of tissue holders depending upon what is being tested, and a range of options when it comes to circulation systems.
The baths can also be integrated with software that can monitor and organize the results for analysis. Most vendors have software that matches the baths they sell and these applications can record data, use advanced algorithms to analyze results, compare and measure responses and even control the valve opening and closing times.
Tissue bath systems have been in use for over a century. They allow for a clean environment where tissue can be tested and responses noted so that we can further the already amazing body of knowledge we have.